ABSTRACT
Background: Throughout any surgical procedure, the immune system is generally activated as a physiological response to the surgical trauma. Cardiopulmonary bypass can trigger the inflammatory response in three ways: direct contact activation of the immune system due to exposer of blood to foreign surfaces, ischaemia-reperfusion injury to vital organs as a result of aortic cross clamping, and splanchnic hypoperfusion. Objective: The aim of the study was to observe the acute phase response variables in Bangladeshi patients and to assess the acute phase response and morbidity of the patients after prolonged bypass surgery.Methods:This cross sectional study was conducted in the Department of Cardiac Surgery, BSMMU from January 2009 to December 2010. Fifty patients were selected for the study and were divided into 2 groups on the basis of cardiopulmonary bypass time. Group I was cardiopulmonary bypass time less than 90 minutes and Group II was more than 90 minutes. Data were stored and analyzed with standard computer software (SPSS-15). P < 0.05 was considered statistically significant.Results:The mean duration of cardiopulmonary bypass (CPB) time (55.76�.8 in group I, 131�.35 in group II; P<0.001) and Aortic cross clamp time (28.48�31 in group I, 83.48�.99 in group II; P<0.001) was higher in group II than group I. Analysis of outcome variables showed that mean postoperative ventilation time was 6.24�20 in group I and 9.16�33 in group II. There was significant difference in the ventilation time between two groups (P<0.001). This study showed that there is a definite relationship of wound infection with the prolonged cardiopulmonary bypass time (P<0.001) and also persistently rising CRP increases the chance of wound infection.Conclusions:We may conclude that prolonged cardiopulmonary bypass time is associated with increased acute phase response and morbidity of Bangladeshi patients.
ABSTRACT
Background: Acute respiratory distress syndrome requiring invasive mechanical ventilation may occur in COVID-19 patients. Barotrauma causes clinically severe pneumothorax, necessitating a chest tube thoracostomy. Acute respiratory syndrome coronavirus 2 is aerosolized during the process, hence specific precautions must be taken to minimize exposure risks to health care workers. Objectives: The objective of the study to diagnosis of Tube thoracostomy during the COVID-19 pandemic to detect and diagnose patients who are positive with the virus.Material & Methods:In Bangladesh, researchers from a tertiary care hospital抯 thoracic surgery section did a retrospective analysis. In total, we had 34 participants. All COVID-19 cases requiring thoracic surgery consultation and management that were admitted to the ICU between July 2020 and January 2022 were included in this study. Iatrogenic pneumothorax and other critical cases not associated with COVID-19 were also eliminated.Results:Thirty-four individuals sought thoracic surgery consultation. Pneumothorax (29.4%), traumatic hemothorax (8.8%), hydropneumothorax (5.9%) and extensive pleural effusion were the causes (55.9%). No post-thoracostomy complications. 6 patients died 3 days after tube thoracostomy who were on artificial breathing and both had more than 81 percent lung involvement (fibrosis) confirmed by CT scan of chest. Surviving patients with thoracostomy tube insertion had better survival than those treated conservatively.Conclusions:In COVID-19 disease, non-iatrogenic pneumothorax, subcutaneous and mediastinal emphysema are associated with worse prognosis and outcomes. Pneumothorax may have a better prognosis and outcome than surgical and mediastinal emphysema.